| Reaction Details |
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 | Report a problem with these data |
| Target | Prolyl 4-hydroxylase subunit alpha-1 |
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| Ligand | BDBM50042876 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1500972 (CHEMBL3587049) |
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| pH | 7.8±n/a |
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| IC50 | 840±n/a nM |
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| Comments | extracted |
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| Citation |  Vasta, JD; Raines, RT Selective inhibition of prolyl 4-hydroxylases by bipyridinedicarboxylates. Bioorg Med Chem23:3081-90 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Prolyl 4-hydroxylase subunit alpha-1 |
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| Name: | Prolyl 4-hydroxylase subunit alpha-1 |
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| Synonyms: | 4-PH alpha-1 | P4HA | P4HA1 | P4HA1_HUMAN | Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1 | Prolyl 4-hydroxylase subunit alpha-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61043.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_103483 |
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| Residue: | 534 |
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| Sequence: | MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA
EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY
FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY
YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR
ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKM
TPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRL
RRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANY
GVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG
TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE
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| BDBM50042876 |
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| n/a |
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| Name | BDBM50042876 |
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| Synonyms: | CHEMBL332005 | [2,2']Bipyridinyl-5,5'-dicarboxylic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C12H8N2O4 |
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| Mol. Mass. | 244.2029 |
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| SMILES | OC(=O)c1ccc(nc1)-c1ccc(cn1)C(O)=O |
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| Structure | 
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