Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Serine/threonine-protein kinase mTOR | ||
Ligand | BDBM50092783 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1501613 (CHEMBL3587365) | ||
IC50 | 10.0±n/a nM | ||
Citation | Mortensen, DS; Perrin-Ninkovic, SM; Shevlin, G; Zhao, J; Packard, G; Bahmanyar, S; Correa, M; Elsner, J; Harris, R; Lee, BG; Papa, P; Parnes, JS; Riggs, JR; Sapienza, J; Tehrani, L; Whitefield, B; Apuy, J; Bisonette, RR; Gamez, JC; Hickman, M; Khambatta, G; Leisten, J; Peng, SX; Richardson, SJ; Cathers, BE; Canan, SS; Moghaddam, MF; Raymon, HK; Worland, P; Narla, RK; Fultz, KE; Sankar, S Discovery of mammalian target of rapamycin (mTOR) kinase inhibitor CC-223. J Med Chem58:5323-33 (2015) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase mTOR | |||
Name: | Serine/threonine-protein kinase mTOR | ||
Synonyms: | FK506-binding protein 12-rapamycin complex-associated protein 1 | FKBP12-rapamycin complex-associated protein | FRAP | FRAP 1 (mTOR) | FRAP1 | FRAP2 | MTOR | MTOR_HUMAN | Mammalian Target of Rapamycin (mTOR) | P42345 | RAFT1 | RAPT1 | Rapamycin and FKBP12 target 1 | Rapamycin target protein | Serine/threonine-protein kinase (mTOR) | mTORC2 | ||
Type: | Rapamycin target protein | ||
Mol. Mass.: | 288917.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P42345 | ||
Residue: | 2549 | ||
Sequence: |
| ||
BDBM50092783 | |||
n/a | |||
Name | BDBM50092783 | ||
Synonyms: | CHEMBL3586404 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H27N5O3 | ||
Mol. Mass. | 397.4708 | ||
SMILES | CO[C@H]1CC[C@@H](CC1)N1C(=O)CNc2ncc(nc12)-c1ccc(nc1)C(C)(C)O |r,wU:2.1,wD:5.8,(2.39,-8.32,;1.33,-7.7,;1.33,-6.16,;-.01,-5.39,;-0,-3.85,;1.33,-3.08,;2.66,-3.85,;2.66,-5.39,;1.33,-1.54,;2.66,-.77,;3.73,-1.38,;2.66,.77,;1.33,1.54,;,.77,;-1.33,1.54,;-2.68,.77,;-2.68,-.77,;-1.33,-1.54,;,-.77,;-4.01,-1.54,;-4.01,-3.08,;-5.35,-3.85,;-6.68,-3.08,;-6.68,-1.54,;-5.35,-.77,;-8.02,-3.85,;-9.08,-3.23,;-9.08,-4.47,;-8.02,-5.08,)| | ||
Structure |