| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bromodomain-containing protein 2 |
|---|
| Ligand | BDBM50096300 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1500550 (CHEMBL3587526) |
|---|
| IC50 | 6310±n/a nM |
|---|
| Citation |  Demont, EH; Chung, CW; Furze, RC; Grandi, P; Michon, AM; Wellaway, C; Barrett, N; Bridges, AM; Craggs, PD; Diallo, H; Dixon, DP; Douault, C; Emmons, AJ; Jones, EJ; Karamshi, BV; Locke, K; Mitchell, DJ; Mouzon, BH; Prinjha, RK; Roberts, AD; Sheppard, RJ; Watson, RJ; Bamborough, P Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors. J Med Chem58:5649-73 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bromodomain-containing protein 2 |
|---|
| Name: | Bromodomain-containing protein 2 |
|---|
| Synonyms: | BRD2 | BRD2_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 2 | Bromodomain-containing protein 2 (BRD2) | KIAA9001 | RING3 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 88085.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P25440 |
|---|
| Residue: | 801 |
|---|
| Sequence: | MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
SDSSSSSSSSSSSDTSDSDSG
|
|
|
|---|
| BDBM50096300 |
|---|
| n/a |
|---|
| Name | BDBM50096300 |
|---|
| Synonyms: | CHEMBL3585452 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H23N5O |
|---|
| Mol. Mass. | 349.4295 |
|---|
| SMILES | Cc1cncc(c1)-c1cnc(NC2CCNCC2)c2[nH]c(=O)c(C)cc12 |
|---|
| Structure | 
|
|---|
Search and Browse
