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TargetMitogen-activated protein kinase 1
LigandBDBM50094304
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1503901 (CHEMBL3593134)
IC50 8.5±n/a nM
Citation Ward, RAColclough, NChallinor, MDebreczeni, JEEckersley, KFairley, GFeron, LFlemington, VGraham, MAGreenwood, RHopcroft, PHoward, TDJames, MJones, CDJones, CRRenshaw, JRoberts, KSnow, LTonge, MYeung, K Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2. J Med Chem58:4790-801 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 1
Name:Mitogen-activated protein kinase 1
Synonyms:ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:Ser/Thr Protein Kinase
Mol. Mass.:41392.76
Organism:Homo sapiens (Human)
Description:P28482
Residue:360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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  Blast E-value cutoff:
BDBM50094304
n/a
NameBDBM50094304
Synonyms:CHEMBL3590118 | US9796700, Compound I-108
TypeSmall organic molecule
Emp. Form.C18H20ClN5O2
Mol. Mass.373.837
SMILESClc1cnc(NC2CCOCC2)nc1Nc1ccccc1NC(=O)C=C
Structure
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