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TargetCatenin beta-1
LigandBDBM50094602
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1504364 (CHEMBL3592701)
Ki 54000±n/a nM
Citation Catrow, JLZhang, YZhang, MJi, H Discovery of Selective Small-Molecule Inhibitors for the฿-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. J Med Chem58:4678-92 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Catenin beta-1
Name:Catenin beta-1
Synonyms:CTNB1_HUMAN | CTNNB | CTNNB1
Type:PROTEIN
Mol. Mass.:85484.08
Organism:Homo sapiens (Human)
Description:ChEMBL_1504364
Residue:781
Sequence:
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTS
QVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPT
NVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSK
KEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL
VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC
LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEA
GGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA
AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM
AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLL
VRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFV
QLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF
RMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFH
SGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTD
L
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50094602
n/a
NameBDBM50094602
Synonyms:CHEMBL3589010 | US9284299, iCRT14 | US9738628, Compound iCRT14
TypeSmall organic molecule
Emp. Form.C21H17N3O2S
Mol. Mass.375.444
SMILESCc1cc(\C=C2/SC(=O)N(C2=O)c2ccccc2)c(C)n1-c1cccnc1
Structure
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