Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCatenin beta-1
LigandBDBM50436058
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1504364 (CHEMBL3592701)
Ki 1800±n/a nM
Citation Catrow, JLZhang, YZhang, MJi, H Discovery of Selective Small-Molecule Inhibitors for the฿-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. J Med Chem58:4678-92 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Catenin beta-1
Name:Catenin beta-1
Synonyms:CTNB1_HUMAN | CTNNB | CTNNB1
Type:PROTEIN
Mol. Mass.:85484.08
Organism:Homo sapiens (Human)
Description:ChEMBL_1504364
Residue:781
Sequence:
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTS
QVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPT
NVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSK
KEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL
VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC
LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEA
GGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA
AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM
AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLL
VRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFV
QLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF
RMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFH
SGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTD
L
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50436058
n/a
NameBDBM50436058
Synonyms:CHEMBL254381 | PNU-74654 | US9738628, Compound PNU-74654
TypeSmall organic molecule
Emp. Form.C19H16N2O3
Mol. Mass.320.3419
SMILESCc1ccc(\C=N\NC(=O)c2ccccc2Oc2ccccc2)o1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: