| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Vesicular acetylcholine transporter |
|---|
| Ligand | BDBM50039623 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1503355 (CHEMBL3590746) |
|---|
| Ki | 0.013000±n/a nM |
|---|
| Citation |  Barthel, C; Sorger, D; Deuther-Conrad, W; Scheunemann, M; Schweiger, S; Jäckel, P; Roghani, A; Steinbach, J; Schüürmann, G; Sabri, O; Brust, P; Wenzel, B New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter - A critical examination of the lead structure. Eur J Med Chem100:50-67 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Vesicular acetylcholine transporter |
|---|
| Name: | Vesicular acetylcholine transporter |
|---|
| Synonyms: | TorVAChT | VACHT_TETCF | VAChT |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 56111.93 |
|---|
| Organism: | Torpedo californica |
|---|
| Description: | ChEMBL_1503355 |
|---|
| Residue: | 515 |
|---|
| Sequence: | MGVTMAVGLAKAAMGKISSAIGERSKRISGAMNEPRRKRKILLVIVCIAMLLDNMLYMVI
VPIIPNYLETIRTYKLVYITTPSNGTNGSLLNSTQRAVLERNPNANEDIQIGVLFASKAI
LQLLSNPFTGTFIDRVGYDIPLLIGLTIMFFSTITFAFGESYAVLFAARSLQGLGSAFAD
TSGIAMIADKYTEESERTQALGIALAFISFGSLVAPPFGGVLYQFAGKWVPFLVLSFVCL
LDGILLLMVVTPFASRTRENMLQGTPIYKLMIDPYIAVVAGALTTCNIPLAFLEPTISNW
MKKTMNASEWQMGITWLPAFFPHILGVYITVKLAAKYPNYQWFYGAVGLVIIGASSCTIP
ACRNFEELIIPLCALCFGIALVDTALLPTLAFLVDIRYVSVYGSVYAIADISYSVAYALG
PIMAGQIVHDLGFVQLNLGMGLVNILYAPALLFLRNVCQMKPSLSERNILLEEGPKGLYD
TIIMEERKAAKEPHGSSSGNHSVHAVLSDQEGYSE
|
|
|
|---|
| BDBM50039623 |
|---|
| n/a |
|---|
| Name | BDBM50039623 |
|---|
| Synonyms: | (2R,3R)-5-Amino-3-(4-phenyl-piperidin-1-yl)-1,2,3,4-tetrahydro-naphthalen-2-ol | CHEMBL87381 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H26N2O |
|---|
| Mol. Mass. | 322.4439 |
|---|
| SMILES | Nc1cccc2C[C@@H](O)[C@@H](Cc12)N1CCC(CC1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
