| Reaction Details |
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 | Report a problem with these data |
| Target | Vesicular acetylcholine transporter |
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| Ligand | BDBM50039613 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1503354 (CHEMBL3590745) |
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| Ki | 1.3±n/a nM |
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| Citation |  Barthel, C; Sorger, D; Deuther-Conrad, W; Scheunemann, M; Schweiger, S; Jäckel, P; Roghani, A; Steinbach, J; Schüürmann, G; Sabri, O; Brust, P; Wenzel, B New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter - A critical examination of the lead structure. Eur J Med Chem100:50-67 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vesicular acetylcholine transporter |
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| Name: | Vesicular acetylcholine transporter |
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| Synonyms: | Slc18a3 | Solute carrier family 18 member 3 | VACHT_RAT | Vacht | Vat | rVAT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56533.41 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1503353 |
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| Residue: | 530 |
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| Sequence: | MEPTAPTGQARAAATKLSEAVGAALQEPQRQRRLVLVIVCVALLLDNMLYMVIVPIVPDY
IAHMRGGSEGPTLVSEVWEPTLPPPTLANASAYLANTSASPTAAGSARSILRPRYPTESE
DVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFA
ARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAG
KRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTT
CNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYG
ALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSV
YAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRS
ERDVLLDEPPQGLYDAVRLREVQGKDGGEPCSPPGPFDGCEDDYNYYSRS
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| BDBM50039613 |
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| n/a |
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| Name | BDBM50039613 |
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| Synonyms: | (2R,3R)-3-(4-Phenyl-piperidin-1-yl)-1,2,3,4-tetrahydro-naphthalen-2-ol | Benzovesamicol | CHEMBL87379 | trans-3-(4-phenylpiperidin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25NO |
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| Mol. Mass. | 307.4293 |
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| SMILES | O[C@@H]1Cc2ccccc2C[C@H]1N1CCC(CC1)c1ccccc1 |r| |
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| Structure | 
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