Reaction Details |
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Target | Protein arginine N-methyltransferase 8 |
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Ligand | BDBM50095436 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1504109 (CHEMBL3591483) |
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IC50 | 347±n/a nM |
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Citation | Mitchell, LH; Drew, AE; Ribich, SA; Rioux, N; Swinger, KK; Jacques, SL; Lingaraj, T; Boriack-Sjodin, PA; Waters, NJ; Wigle, TJ; Moradei, O; Jin, L; Riera, T; Porter-Scott, M; Moyer, MP; Smith, JJ; Chesworth, R; Copeland, RA Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound. ACS Med Chem Lett6:655-9 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein arginine N-methyltransferase 8 |
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Name: | Protein arginine N-methyltransferase 8 |
Synonyms: | ANM8_HUMAN | HRMT1L3 | HRMT1L3 | HRMT1L4 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4 | PRMT8 | Protein arginine N-methyltransferase 8 | Protein arginine N-methyltransferase 8 (PRMT8) | Protein arginine methyltransferase 8 (PRMT8) |
Type: | Protein |
Mol. Mass.: | 45293.70 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 394 |
Sequence: | MGMKHSSRCLLLRRKMAENAAESTEVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGK
MSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGS
GTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVD
IIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWE
NVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQR
NDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISM
KPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR
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BDBM50095436 |
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n/a |
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Name | BDBM50095436 |
Synonyms: | CHEMBL3589043 |
Type | Small organic molecule |
Emp. Form. | C23H29N5O2 |
Mol. Mass. | 407.5087 |
SMILES | CNCCN(C)Cc1n[nH]cc1-c1ccc(Oc2cccc(c2)C(=O)N(C)C)cc1 |
Structure |
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