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TargetProtein arginine N-methyltransferase 8
LigandBDBM50095436
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1504109 (CHEMBL3591483)
IC50 347±n/a nM
Citation Mitchell, LHDrew, AERibich, SARioux, NSwinger, KKJacques, SLLingaraj, TBoriack-Sjodin, PAWaters, NJWigle, TJMoradei, OJin, LRiera, TPorter-Scott, MMoyer, MPSmith, JJChesworth, RCopeland, RA Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound. ACS Med Chem Lett6:655-9 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein arginine N-methyltransferase 8
Name:Protein arginine N-methyltransferase 8
Synonyms:ANM8_HUMAN | HRMT1L3 | HRMT1L3 | HRMT1L4 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4 | PRMT8 | Protein arginine N-methyltransferase 8 | Protein arginine N-methyltransferase 8 (PRMT8) | Protein arginine methyltransferase 8 (PRMT8)
Type:Protein
Mol. Mass.:45293.70
Organism:Homo sapiens (Human)
Description:n/a
Residue:394
Sequence:
MGMKHSSRCLLLRRKMAENAAESTEVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGK
MSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGS
GTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVD
IIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWE
NVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQR
NDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISM
KPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50095436
n/a
NameBDBM50095436
Synonyms:CHEMBL3589043
TypeSmall organic molecule
Emp. Form.C23H29N5O2
Mol. Mass.407.5087
SMILESCNCCN(C)Cc1n[nH]cc1-c1ccc(Oc2cccc(c2)C(=O)N(C)C)cc1
Structure
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