| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 8 |
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| Ligand | BDBM50095439 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1504109 (CHEMBL3591483) |
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| IC50 | 1500±n/a nM |
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| Citation |  Mitchell, LH; Drew, AE; Ribich, SA; Rioux, N; Swinger, KK; Jacques, SL; Lingaraj, T; Boriack-Sjodin, PA; Waters, NJ; Wigle, TJ; Moradei, O; Jin, L; Riera, T; Porter-Scott, M; Moyer, MP; Smith, JJ; Chesworth, R; Copeland, RA Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound. ACS Med Chem Lett6:655-9 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 8 |
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| Name: | Protein arginine N-methyltransferase 8 |
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| Synonyms: | ANM8_HUMAN | HRMT1L3 | HRMT1L3 | HRMT1L4 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4 | PRMT8 | Protein arginine N-methyltransferase 8 | Protein arginine N-methyltransferase 8 (PRMT8) | Protein arginine methyltransferase 8 (PRMT8) |
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| Type: | Protein |
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| Mol. Mass.: | 45293.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 394 |
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| Sequence: | MGMKHSSRCLLLRRKMAENAAESTEVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGK
MSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGS
GTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVD
IIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWE
NVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQR
NDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISM
KPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR
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| BDBM50095439 |
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| n/a |
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| Name | BDBM50095439 |
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| Synonyms: | CHEMBL3589041 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H32N6O |
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| Mol. Mass. | 432.5612 |
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| SMILES | CN(CCN)Cc1c[nH]nc1-c1ccc(cc1)N1CCN(CC1)C(=O)Cc1ccccc1 |
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| Structure | 
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