| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 8 |
|---|
| Ligand | BDBM50095349 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1504109 (CHEMBL3591483) |
|---|
| IC50 | 70±n/a nM |
|---|
| Citation |  Mitchell, LH; Drew, AE; Ribich, SA; Rioux, N; Swinger, KK; Jacques, SL; Lingaraj, T; Boriack-Sjodin, PA; Waters, NJ; Wigle, TJ; Moradei, O; Jin, L; Riera, T; Porter-Scott, M; Moyer, MP; Smith, JJ; Chesworth, R; Copeland, RA Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound. ACS Med Chem Lett6:655-9 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein arginine N-methyltransferase 8 |
|---|
| Name: | Protein arginine N-methyltransferase 8 |
|---|
| Synonyms: | ANM8_HUMAN | HRMT1L3 | HRMT1L3 | HRMT1L4 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4 | PRMT8 | Protein arginine N-methyltransferase 8 | Protein arginine N-methyltransferase 8 (PRMT8) | Protein arginine methyltransferase 8 (PRMT8) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 45293.70 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 394 |
|---|
| Sequence: | MGMKHSSRCLLLRRKMAENAAESTEVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGK
MSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGS
GTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVD
IIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWE
NVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQR
NDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISM
KPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR
|
|
|
|---|
| BDBM50095349 |
|---|
| n/a |
|---|
| Name | BDBM50095349 |
|---|
| Synonyms: | CHEMBL3589035 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H22ClF3N4O |
|---|
| Mol. Mass. | 390.831 |
|---|
| SMILES | CC(C)Oc1c(Cl)cc(cc1C(F)(F)F)-c1c[nH]nc1CN(C)CCN |
|---|
| Structure | 
|
|---|
Search and Browse
