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TargetProtein arginine N-methyltransferase 6
LigandBDBM50095352
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1504108 (CHEMBL3591482)
IC50 23±n/a nM
Citation Mitchell, LHDrew, AERibich, SARioux, NSwinger, KKJacques, SLLingaraj, TBoriack-Sjodin, PAWaters, NJWigle, TJMoradei, OJin, LRiera, TPorter-Scott, MMoyer, MPSmith, JJChesworth, RCopeland, RA Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound. ACS Med Chem Lett6:655-9 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein arginine N-methyltransferase 6
Name:Protein arginine N-methyltransferase 6
Synonyms:ANM6_HUMAN | HRMT1L6 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 | Histone-arginine N-methyltransferase PRMT6 | PRMT6 | Protein arginine methyltransferase 6 (PRMT6)
Type:Protein
Mol. Mass.:41928.48
Organism:Homo sapiens (Human)
Description:n/a
Residue:375
Sequence:
MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERDQLYYECYSDVSVHEEM
IADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQA
REVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKE
GGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQG
LSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGE
SEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYK
VGDQEEKTKDFAMED
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BDBM50095352
n/a
NameBDBM50095352
Synonyms:CHEMBL3589032
TypeSmall organic molecule
Emp. Form.C18H27ClN4O
Mol. Mass.350.886
SMILESCNCCN(C)Cc1cnn(C)c1-c1ccc(OC(C)C)c(Cl)c1
Structure
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