Reaction Details | |||
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Target | Protein arginine N-methyltransferase 1 [11-371] | ||
Ligand | BDBM50095441 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1504110 (CHEMBL3591484) | ||
IC50 | 119±n/a nM | ||
Citation | Mitchell, LH; Drew, AE; Ribich, SA; Rioux, N; Swinger, KK; Jacques, SL; Lingaraj, T; Boriack-Sjodin, PA; Waters, NJ; Wigle, TJ; Moradei, O; Jin, L; Riera, T; Porter-Scott, M; Moyer, MP; Smith, JJ; Chesworth, R; Copeland, RA Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound. ACS Med Chem Lett6:655-9 (2015) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Protein arginine N-methyltransferase 1 [11-371] | |||
Name: | Protein arginine N-methyltransferase 1 [11-371] | ||
Synonyms: | ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1 | ||
Type: | Protein | ||
Mol. Mass.: | 41506.52 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q99873[11-371] | ||
Residue: | 361 | ||
Sequence: |
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BDBM50095441 | |||
n/a | |||
Name | BDBM50095441 | ||
Synonyms: | CHEMBL3589039 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H38N4O3 | ||
Mol. Mass. | 442.5942 | ||
SMILES | CNCCN(C)Cc1c[nH]nc1-c1ccc(O[C@H]2C[C@@H](C2)OCCC2CCOCC2)cc1 |r,wU:17.17,wD:19.22,(9.1,4.97,;7.93,4.58,;7.61,3.08,;6.15,2.59,;5.83,1.08,;6.75,.26,;4.37,.6,;4.06,-.91,;5.09,-2.05,;4.31,-3.38,;2.81,-3.06,;2.67,-1.54,;1.33,-.77,;1.33,.77,;,1.54,;-1.33,.77,;-2.67,1.54,;-4,.77,;-4.35,-.7,;-5.84,-.3,;-5.45,1.19,;-7.17,-1.07,;-8.5,-.31,;-9.84,-1.08,;-11.17,-.31,;-12.51,-1.08,;-13.84,-.31,;-13.84,1.23,;-12.51,2,;-11.17,1.23,;-1.33,-.77,;,-1.54,)| | ||
Structure |