Reaction Details |
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Target | Aurora kinase C |
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Ligand | BDBM50095952 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1505328 (CHEMBL3595096) |
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IC50 | >1000±n/a nM |
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Citation | Nakajima, Y; Inoue, T; Nakai, K; Mukoyoshi, K; Hamaguchi, H; Hatanaka, K; Sasaki, H; Tanaka, A; Takahashi, F; Kunikawa, S; Usuda, H; Moritomo, A; Higashi, Y; Inami, M; Shirakami, S Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3. Bioorg Med Chem23:4871-83 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase C |
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Name: | Aurora kinase C |
Synonyms: | AIE2 | AIK3 | AIRK3 | ARK3 | AURKC | AURKC_HUMAN | Aurora Kinase C (Aurora-C) | Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora-C/INCENP | Aurora/Ipl1-related kinase 3 | Aurora/Ipl1/Eg2 protein 2 | STK13 | Serine/threonine-protein kinase 13 | Serine/threonine-protein kinase Aurora-C |
Type: | Enzyme |
Mol. Mass.: | 35602.43 |
Organism: | Homo sapiens (Human) |
Description: | Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system. |
Residue: | 309 |
Sequence: | MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
LPPCAQMAS
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BDBM50095952 |
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n/a |
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Name | BDBM50095952 |
Synonyms: | CHEMBL3593777 |
Type | Small organic molecule |
Emp. Form. | C19H18FN7O |
Mol. Mass. | 379.3909 |
SMILES | NC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(C[C@@H]1F)c1ccc(cn1)C#N |r| |
Structure |
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