| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM50033843 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1505669 (CHEMBL3594589) |
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| Ki | 0.310000±n/a nM |
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| Citation |  Stroth, N; Niso, M; Colabufo, NA; Perrone, R; Svenningsson, P; Lacivita, E; Leopoldo, M Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of฿-arrestin-2. Bioorg Med Chem23:4824-30 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A |
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| Type: | n/a |
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| Mol. Mass.: | 46122.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 422 |
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| Sequence: | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ
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| BDBM50033843 |
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| n/a |
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| Name | BDBM50033843 |
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| Synonyms: | 1-[3-(5-Methoxy-3,4-dihydro-2H-naphthalen-1-ylidene)-propyl]-4-pyridin-2-yl-piperazine | 1-{3-[5-Methoxy-3,4-dihydro-2H-naphthalen-(1E)-ylidene]-propyl}-4-pyridin-2-yl-piperazine | CHEMBL140406 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H29N3O |
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| Mol. Mass. | 363.4959 |
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| SMILES | COc1cccc2\C(CCCc12)=C\CCN1CCN(CC1)c1ccccn1 |
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| Structure | 
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