| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Ligand | BDBM50300015 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1505693 (CHEMBL3594613) |
|---|
| IC50 | 19000±n/a nM |
|---|
| Citation |  Abdullah, I; Chee, CF; Lee, YK; Thunuguntla, SS; Satish Reddy, K; Nellore, K; Antony, T; Verma, J; Mun, KW; Othman, S; Subramanya, H; Rahman, NA Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH. Bioorg Med Chem23:4669-80 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 42881.33 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q02127 |
|---|
| Residue: | 395 |
|---|
| Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
|
|
|
|---|
| BDBM50300015 |
|---|
| n/a |
|---|
| Name | BDBM50300015 |
|---|
| Synonyms: | 2-(4-(Pyridin-3-yl)phenyl)-1H-benzo[d]imidazole-4-carboxamide | 2-(4-pyridine-3-ylphenyl)-1H-benzimidazole-4-carboxamide | CHEMBL571285 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H14N4O |
|---|
| Mol. Mass. | 314.3407 |
|---|
| SMILES | NC(=O)c1cccc2[nH]c(nc12)-c1ccc(cc1)-c1cccnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
