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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase PAK 4 | ||
| Ligand | BDBM50096230 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1505870 (CHEMBL3595327) | ||
| Ki | 621±n/a nM | ||
| Citation |  Rudolph, J; Aliagas, I; Crawford, JJ; Mathieu, S; Lee, W; Chao, Q; Dong, P; Rouge, L; Wang, W; Heise, C; Murray, LJ; La, H; Liu, Y; Manning, G; Diederich, F; Hoeflich, KP Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series. ACS Med Chem Lett6:711-5 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase PAK 4 | |||
| Name: | Serine/threonine-protein kinase PAK 4 | ||
| Synonyms: | KIAA1142 | PAK4 | PAK4_HUMAN | p21-Activated kinase 4 (PAK4) | ||
| Type: | Protein | ||
| Mol. Mass.: | 64098.01 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O96013 | ||
| Residue: | 591 | ||
| Sequence: |
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| BDBM50096230 | |||
| n/a | |||
| Name | BDBM50096230 | ||
| Synonyms: | CHEMBL3594178 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H32N8O | ||
| Mol. Mass. | 412.5318 | ||
| SMILES | CCN(C[C@H]1CC[C@H](N)CC1)c1nccc(Nc2cc([nH]n2)[C@H]2CCN(C)C2=O)n1 |r,wU:4.3,22.23,wD:7.7,(-3.74,3.69,;-2.68,3.08,;-2.67,1.54,;-4,.77,;-5.34,1.53,;-6.67,.76,;-8.01,1.53,;-8.01,3.07,;-9.07,3.69,;-6.67,3.84,;-5.34,3.07,;-1.33,.77,;,1.54,;1.33,.77,;1.33,-.77,;,-1.54,;0,-3.08,;1.34,-3.85,;1.49,-5.37,;2.99,-5.68,;3.76,-4.35,;2.72,-3.21,;3.62,-7.09,;5.14,-7.26,;5.43,-8.77,;4.08,-9.51,;3.92,-10.74,;2.96,-8.46,;1.74,-8.68,;-1.33,-.77,)| | ||
| Structure | 
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