| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase CSK |
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| Ligand | BDBM50096279 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1495634 (CHEMBL3578505) |
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| IC50 | 290±n/a nM |
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| Citation |  Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells. J Med Chem58:4165-79 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase CSK |
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| Name: | Tyrosine-protein kinase CSK |
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| Synonyms: | C-SRC kinase | C-src tyrosine kinase | CSK | CSK_HUMAN | Protein-tyrosine kinase CYL | Tyrosine Kinase CSK |
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| Type: | Tyrosine-protein kinase |
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| Mol. Mass.: | 50707.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41240 |
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| Residue: | 450 |
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| Sequence: | MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
NCWHLDAAMRPSFLQLREQLEHIKTHELHL
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| BDBM50096279 |
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| n/a |
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| Name | BDBM50096279 |
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| Synonyms: | CHEMBL3577124 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H29FN6O |
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| Mol. Mass. | 424.5144 |
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| SMILES | CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)NCCC(C)(C)C)c(F)cc1C |
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| Structure | 
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