| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PAK 4 |
|---|
| Ligand | BDBM50097137 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1499558 (CHEMBL3584416) |
|---|
| Ki | 1900±n/a nM |
|---|
| Citation |  Crawford, JJ; Lee, W; Aliagas, I; Mathieu, S; Hoeflich, KP; Zhou, W; Wang, W; Rouge, L; Murray, L; La, H; Liu, N; Fan, PW; Cheong, J; Heise, CE; Ramaswamy, S; Mintzer, R; Liu, Y; Chao, Q; Rudolph, J Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors. J Med Chem58:5121-36 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase PAK 4 |
|---|
| Name: | Serine/threonine-protein kinase PAK 4 |
|---|
| Synonyms: | KIAA1142 | PAK4 | PAK4_HUMAN | p21-Activated kinase 4 (PAK4) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 64098.01 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O96013 |
|---|
| Residue: | 591 |
|---|
| Sequence: | MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE
PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL
SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP
QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR
ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY
WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK
VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
|
|
|
|---|
| BDBM50097137 |
|---|
| n/a |
|---|
| Name | BDBM50097137 |
|---|
| Synonyms: | CHEMBL3580971 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H20N8 |
|---|
| Mol. Mass. | 360.4157 |
|---|
| SMILES | Cn1cnc2ccc(CNc3nccc(Nc4cc([nH]n4)C4CC4)n3)cc12 |
|---|
| Structure | 
|
|---|
Search and Browse
