| Reaction Details |
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 | Report a problem with these data |
| Target | Activated CDC42 kinase 1 |
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| Ligand | BDBM50097393 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1501910 (CHEMBL3588250) |
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| IC50 | 11±n/a nM |
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| Citation |  Smith, CR; Dougan, DR; Komandla, M; Kanouni, T; Knight, B; Lawson, JD; Sabat, M; Taylor, ER; Vu, P; Wyrick, C Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton's Tyrosine Kinase. J Med Chem58:5437-44 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Activated CDC42 kinase 1 |
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| Name: | Activated CDC42 kinase 1 |
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| Synonyms: | ACK1 | ACK1_HUMAN | Activated CDC42 kinase 1 (ACK-1) | TNK2 | Tyrosine kinase non-receptor protein 2 |
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| Type: | Protein |
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| Mol. Mass.: | 114577.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07912 |
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| Residue: | 1038 |
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| Sequence: | MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW
EAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCL
IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA
MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM
GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE
SLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI
YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRA
ENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPD
RIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKKPTYDPVSEDQDPLSSDFKRLGLRKP
GLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLL
DETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVP
AGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQA
PAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPP
REPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRA
GPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEPTPLPVPLLLPPPSTP
APAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPAD
KIQMAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLGLRPRGECHKVLEMFDWNL
EQAGCHLLGSWGPAHHKR
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| BDBM50097393 |
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| n/a |
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| Name | BDBM50097393 |
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| Synonyms: | CHEMBL3586447 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14N6O |
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| Mol. Mass. | 318.3327 |
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| SMILES | Cc1cc2cn[nH]c2cc1-c1cccc2c(N)c(nnc12)C(N)=O |
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| Structure | 
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