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TargetSerine/threonine-protein kinase Aurora-A
LigandBDBM50097414
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1502089
IC50 33±n/a nM
Citation Sells TBChau REcsedy JAGershman REHoar KHuck JJanowick DAKadambi VJLeRoy PJStirling MStroud SGVos TJWeatherhead GSWysong DRZhang MBalani SKBolen JBManfredi MGClaiborne CF MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors. ACS Med Chem Lett 6:630-4 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase Aurora-A
Name:Serine/threonine-protein kinase Aurora-A
Synonyms:Aurora Kinase A (Aurora-A) | Aurora kinase A | Aurora-family kinase 1 | Aurora/IPL1-related kinase 1 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase Ayk1
Type:Enzyme
Mol. Mass.:44791.66
Organism:Mus musculus (mouse)
Description:n/a
Residue:395
Sequence:
MDRCKENCVSRPVKTTVPFGPKRVLVTEQIPSQNLGSASSGQAQRVLCPSNSQRVPSQAQ
KLGAGQKPAPKQLPAASVPRPVSRLNNPQKNEQPAASGNDSEKEQASLQKTEDTKKRQWT
LEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLR
HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS
KRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTMCGTLDYLPPEMIEGRMHDEK
VDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNAS
QRLTLAEVLEHPWIKANSSKPPTGHTSKEPTSKSS
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  Blast E-value cutoff:
BDBM50097414
n/a
NameBDBM50097414
Synonyms:CHEMBL3586468
TypeSmall organic molecule
Emp. Form.C25H16ClFN4O2
Mol. Mass.458.872
SMILESOC(=O)c1ccc(Nc2ncc3CN=C(c4ccccc4F)c4cc(Cl)ccc4-c3n2)cc1 |t:13|
Structure
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