| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK2 |
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| Ligand | BDBM50097861 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1502246 (CHEMBL3591182) |
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| IC50 | 610±n/a nM |
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| Citation |  Falke, H; Chaikuad, A; Becker, A; Loaëc, N; Lozach, O; Abu Jhaisha, S; Becker, W; Jones, PG; Preu, L; Baumann, K; Knapp, S; Meijer, L; Kunick, C 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A. J Med Chem58:3131-43 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase CLK2 |
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| Name: | Dual specificity protein kinase CLK2 |
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| Synonyms: | CDC-like kinase 2 | CLK2_MOUSE | Clk2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60021.57 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1502246 |
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| Residue: | 499 |
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| Sequence: | MPHPRRYHSSERGSRGSYHEHYQSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYD
DHSSDRRLYDRRYCGSYRRNDYSRDRGEAYYDTDFRQSYEYHRENSSYRSQRSSRRKHRR
RRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCV
DHRRGGTQVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCI
SFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNS
DYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQP
CDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPVPSRMIRKTRKQKYFYRGRLDW
DENTSAGRYVRENCKPLRRYLTSEAEDHHQLFDLIENMLEYEPAKRLTLGEALQHPFFAC
LRTEPPNTKLWDSSRDISR
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| BDBM50097861 |
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| n/a |
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| Name | BDBM50097861 |
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| Synonyms: | CHEMBL3589672 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H8BrIN2O2 |
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| Mol. Mass. | 467.055 |
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| SMILES | OC(=O)c1nc2ccc(I)cc2c2[nH]c3c(Br)cccc3c12 |
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| Structure | 
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