Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetDual specificity protein kinase CLK4
LigandBDBM50097867
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1502248
IC50 45±n/a nM
Citation Falke HChaikuad ABecker ALoac NLozach OAbu Jhaisha SBecker WJones PGPreu LBaumann KKnapp SMeijer LKunick C 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A. J Med Chem 58:3131-43 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity protein kinase CLK4
Name:Dual specificity protein kinase CLK4
Synonyms:CDC-like kinase 4
Type:PROTEIN
Mol. Mass.:57374.39
Organism:Mus musculus
Description:ChEMBL_1502248
Residue:481
Sequence:
MRHSKRTHCPDWDSRESWGHESYSGSHKRKRRSHSSTQENRHCKPHHQFKDSDCHYLEAR
CLNERDYRDRRYIDEYRNDYCEGYVPRHYHRDVESTYRIHCSKSSVRSRRSSPKRKRNRP
CASHQSHSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHG
MDGLHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFE
LLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYV
VKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDV
WSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPAHMIQKTRKRKYFHHNQLDWDEH
SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPARRITLDEALQHPFFDLLKR
K
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50097867
n/a
NameBDBM50097867
Synonyms:CHEMBL3589660
TypeSmall organic molecule
Emp. Form.C16H9ClN2O2
Mol. Mass.296.708
SMILESOC(=O)c1nc2ccccc2c2[nH]c3c(Cl)cccc3c12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: