| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK4 |
|---|
| Ligand | BDBM50097858 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1502248 (CHEMBL3591184) |
|---|
| IC50 | 350±n/a nM |
|---|
| Citation |  Falke, H; Chaikuad, A; Becker, A; Loaëc, N; Lozach, O; Abu Jhaisha, S; Becker, W; Jones, PG; Preu, L; Baumann, K; Knapp, S; Meijer, L; Kunick, C 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A. J Med Chem58:3131-43 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity protein kinase CLK4 |
|---|
| Name: | Dual specificity protein kinase CLK4 |
|---|
| Synonyms: | CDC-like kinase 4 | CLK4_MOUSE | Clk4 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 57374.39 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_1502248 |
|---|
| Residue: | 481 |
|---|
| Sequence: | MRHSKRTHCPDWDSRESWGHESYSGSHKRKRRSHSSTQENRHCKPHHQFKDSDCHYLEAR
CLNERDYRDRRYIDEYRNDYCEGYVPRHYHRDVESTYRIHCSKSSVRSRRSSPKRKRNRP
CASHQSHSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHG
MDGLHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFE
LLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYV
VKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDV
WSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPAHMIQKTRKRKYFHHNQLDWDEH
SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPARRITLDEALQHPFFDLLKR
K
|
|
|
|---|
| BDBM50097858 |
|---|
| n/a |
|---|
| Name | BDBM50097858 |
|---|
| Synonyms: | CHEMBL3589669 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H13ClN2O3 |
|---|
| Mol. Mass. | 340.76 |
|---|
| SMILES | CCOc1ccc2c3[nH]c4c(Cl)cccc4c3c(nc2c1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
