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TargetDual specificity protein kinase CLK4
LigandBDBM50097860
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1502248
IC50 3600±n/a nM
Citation Falke HChaikuad ABecker ALoac NLozach OAbu Jhaisha SBecker WJones PGPreu LBaumann KKnapp SMeijer LKunick C 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A. J Med Chem 58:3131-43 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity protein kinase CLK4
Name:Dual specificity protein kinase CLK4
Synonyms:CDC-like kinase 4
Type:PROTEIN
Mol. Mass.:57374.39
Organism:Mus musculus
Description:ChEMBL_1502248
Residue:481
Sequence:
MRHSKRTHCPDWDSRESWGHESYSGSHKRKRRSHSSTQENRHCKPHHQFKDSDCHYLEAR
CLNERDYRDRRYIDEYRNDYCEGYVPRHYHRDVESTYRIHCSKSSVRSRRSSPKRKRNRP
CASHQSHSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHG
MDGLHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFE
LLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYV
VKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDV
WSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPAHMIQKTRKRKYFHHNQLDWDEH
SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPARRITLDEALQHPFFDLLKR
K
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50097860
n/a
NameBDBM50097860
Synonyms:CHEMBL3589671
TypeSmall organic molecule
Emp. Form.C16H8ClIN2O2
Mol. Mass.422.604
SMILESOC(=O)c1nc2ccc(I)cc2c2[nH]c3c(Cl)cccc3c12
Structure
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