| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase BAZ1B |
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| Ligand | BDBM50098305 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1502825 (CHEMBL3591385) |
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| Kd | <100000±n/a nM |
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| Citation |  Bamborough, P; Chung, CW; Furze, RC; Grandi, P; Michon, AM; Sheppard, RJ; Barnett, H; Diallo, H; Dixon, DP; Douault, C; Jones, EJ; Karamshi, B; Mitchell, DJ; Prinjha, RK; Rau, C; Watson, RJ; Werner, T; Demont, EH Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors. J Med Chem58:6151-78 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase BAZ1B |
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| Name: | Tyrosine-protein kinase BAZ1B |
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| Synonyms: | BAZ1B | BAZ1B_HUMAN | Bromodomain adjacent to zinc finger domain protein 1B | Tyrosine-protein kinase BAZ1B | WBSC10 | WBSC10 | WBSCR10 | WBSCR9 | WSTF | Williams syndrome transcription factor | Williams-Beuren syndrome chromosomal region 10 protein | Williams-Beuren syndrome chromosomal region 9 protein | hWALp2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 170941.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109819 |
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| Residue: | 1483 |
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| Sequence: | MAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQL
THKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEEC
DFEVGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVV
KEDEGRRESINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQNEDKIISNVPADS
LIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMT
LNPSTKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSK
SPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKKPGKHSDKPLKAKGRSKGILNGQKSTGN
SKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIA
YYKENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSE
EQRKEYLKKKREELKKKLKEKAKERREKEMLERLEKQKRYEDQELTGKNLPAFRLVDTPE
GLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQ
TLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFE
DNEVQDEFLEKLETSEFFELTSEEKLQILTALCHRILMTYSVQDHMETRQQMSAELWKER
LAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMIS
AVKSRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRR
TPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSIDYRFNHHCKDHTVSGDEDYCPRSKKAN
LGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKER
LEKRYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEF
EARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKRRKLQSEDSAKTEEVDEEKKMV
EEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLI
LCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDESD
EEEEEEEEEEEEEDYEVAGLRLRPRKTIRGKHSVIPPAARSGRRPGKKPHSTRRSQPKAP
PVDDAEVDELVLQTKRSSRRQSLELQKCEEILHKIVKYRFSWPFREPVTRDEAEDYYDVI
THPMDFQTVQNKCSCGSYRSVQEFLTDMKQVFTNAEVYNCRGSHVLSCMVKTEQCLVALL
HKHLPGHPYVRRKRKKFPDRLAEDEGDSEPEAVGQSRGRRQKK
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| BDBM50098305 |
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| n/a |
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| Name | BDBM50098305 |
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| Synonyms: | CHEMBL3590405 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H34N4O4S |
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| Mol. Mass. | 510.648 |
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| SMILES | Cc1cncc(c1)-c1ccc(N[C@@H]2CCNC[C@H]2OCC2CCS(=O)(=O)CC2)c2[nH]c(=O)c(C)cc12 |r| |
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| Structure | 
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