Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50098352 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1505008 (CHEMBL3595790) |
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Ki | 4.3±n/a nM |
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Citation | Ibrahim, DA; Lasheen, DS; Zaky, MY; Ibrahim, AW; Vullo, D; Ceruso, M; Supuran, CT; Abou El Ella, DA Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII. Bioorg Med Chem23:4989-99 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50098352 |
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n/a |
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Name | BDBM50098352 |
Synonyms: | CHEMBL3594420 |
Type | Small organic molecule |
Emp. Form. | C20H20N8O4S6 |
Mol. Mass. | 628.814 |
SMILES | NS(=O)(=O)c1ccc2nc(NC(=S)N3CCN(CC3)C(=S)Nc3nc4ccc(cc4s3)S(N)(=O)=O)sc2c1 |
Structure |
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