| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor IX |
|---|
| Ligand | BDBM50098599 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1504783 (CHEMBL3595068) |
|---|
| Ki | >35000±n/a nM |
|---|
| Citation |  Priestley, ES; Cheney, DL; DeLucca, I; Wei, A; Luettgen, JM; Rendina, AR; Wong, PC; Wexler, RR Structure-Based Design of Macrocyclic Coagulation Factor VIIa Inhibitors. J Med Chem58:6225-36 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor IX |
|---|
| Name: | Coagulation factor IX |
|---|
| Synonyms: | Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51768.83 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00740 |
|---|
| Residue: | 461 |
|---|
| Sequence: | MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
|
|
|
|---|
| BDBM50098599 |
|---|
| n/a |
|---|
| Name | BDBM50098599 |
|---|
| Synonyms: | CHEMBL3594310 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H31N5O4S |
|---|
| Mol. Mass. | 557.663 |
|---|
| SMILES | CCS(=O)(=O)c1ccc2NC(=O)CCCc3ccc(cc3)[C@@H](Nc3ccc4c(N)nccc4c3)C(=O)NCc1c2 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
