| Reaction Details |
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 | Report a problem with these data |
| Target | Rap guanine nucleotide exchange factor 4 |
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| Ligand | BDBM50098712 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1504797 (CHEMBL3595150) |
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| IC50 | 2500±n/a nM |
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| Citation |  Ye, N; Zhu, Y; Chen, H; Liu, Z; Mei, FC; Wild, C; Chen, H; Cheng, X; Zhou, J Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists. J Med Chem58:6033-47 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Rap guanine nucleotide exchange factor 4 |
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| Name: | Rap guanine nucleotide exchange factor 4 |
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| Synonyms: | Cgef2 | Cgef2 | EPAC 2 | Epac2 | Exchange factor directly activated by cAMP 2 | Exchange protein directly activated by cAMP 2 | RPGF4_MOUSE | Rap guanine nucleotide exchange factor 4 | Rapgef4 | cAMP-GEFII | cAMP-dependent Rap1 guanine-nucleotide exchange factor | cAMP-regulated guanine nucleotide exchange factor II |
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| Type: | PROTEIN |
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| Mol. Mass.: | 115497.71 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_109832 |
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| Residue: | 1011 |
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| Sequence: | MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGY
YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
TPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT
PLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE
LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLP
TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHL
STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD
FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV
PAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVF
MPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMA
FLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK
RQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEK
VVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQM
TTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKR
VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM
DPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART
VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
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| BDBM50098712 |
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| n/a |
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| Name | BDBM50098712 |
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| Synonyms: | CHEMBL3593336 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14ClFN4O2 |
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| Mol. Mass. | 348.759 |
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| SMILES | CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(F)cc(Cl)c1)\C#N |
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| Structure | 
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