| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
|---|
| Ligand | BDBM50100519 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1456719 (CHEMBL3371009) |
|---|
| IC50 | <1.3±n/a nM |
|---|
| Citation |  Lee, KS; Liu, JY; Wagner, KM; Pakhomova, S; Dong, H; Morisseau, C; Fu, SH; Yang, J; Wang, P; Ulu, A; Mate, CA; Nguyen, LV; Hwang, SH; Edin, ML; Mara, AA; Wulff, H; Newcomer, ME; Zeldin, DC; Hammock, BD Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J Med Chem57:7016-30 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bifunctional epoxide hydrolase 2 |
|---|
| Name: | Bifunctional epoxide hydrolase 2 |
|---|
| Synonyms: | Ephx2 | Epoxide hydrolase 2 | HYES_RAT |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 62337.15 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1465995 |
|---|
| Residue: | 554 |
|---|
| Sequence: | MALRVAAFDLDGVLALPSIAGVLRHTEEALALPRDFLLGAFQMKFPEGPTEQLMKGKITF
SQWVPLMDESCRKSSKACGASLPENFSISEIFSQAMAARSINRPMLQAAAALKKKGFTTC
IVTNNWLDDSDKRDILAQMMCELSQHFDFLIESCQVGMIKPEPQIYKFVLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVRDTASALRELEKVTGTQFPEAPLPVPCSPNDVSHGYV
TVKPGIRLHFVEMGSGPAICLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCEEMVTFLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVASLNTPL
MPPNPEVSPMEVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRTSDDMGLLTVNK
ATEMGGILVGTPEDPKVSKITTEEEIEYYIQQFKKSGFRGPLNWYRNTERNWKWSCKALG
RKILVPALMVTAEKDIVLRPEMSKNMENWIPFLKRGHIEDCGHWTQIEKPAEVNQILIKW
LKTEIQNPSVTSKI
|
|
|
|---|
| BDBM50100519 |
|---|
| n/a |
|---|
| Name | BDBM50100519 |
|---|
| Synonyms: | CHEMBL3327067 | US10377744, Compound No. 2391 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H24F3N3O2 |
|---|
| Mol. Mass. | 371.3973 |
|---|
| SMILES | CC[C@H](C)C(=O)N1CCC(CC1)NC(=O)Nc1ccc(cc1)C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
