Reaction Details |
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Target | Bifunctional epoxide hydrolase 2 |
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Ligand | BDBM50100522 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1455803 (CHEMBL3361515) |
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Ki | 0.440000±n/a nM |
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Citation | Lee, KS; Liu, JY; Wagner, KM; Pakhomova, S; Dong, H; Morisseau, C; Fu, SH; Yang, J; Wang, P; Ulu, A; Mate, CA; Nguyen, LV; Hwang, SH; Edin, ML; Mara, AA; Wulff, H; Newcomer, ME; Zeldin, DC; Hammock, BD Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J Med Chem57:7016-30 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bifunctional epoxide hydrolase 2 |
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Name: | Bifunctional epoxide hydrolase 2 |
Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic |
Type: | Enzyme |
Mol. Mass.: | 62613.07 |
Organism: | Homo sapiens (Human) |
Description: | P34913 |
Residue: | 555 |
Sequence: | MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL
SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA
ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV
VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG
YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS
APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT
PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH
KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL
GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK
WLDSDARNPPVVSKM
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BDBM50100522 |
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n/a |
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Name | BDBM50100522 |
Synonyms: | CHEMBL3327087 |
Type | Small organic molecule |
Emp. Form. | C17H24F3N3O4S |
Mol. Mass. | 423.45 |
SMILES | CCCCS(=O)(=O)N1CCC(CC1)NC(=O)Nc1ccc(OC(F)(F)F)cc1 |
Structure |
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