Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Nociceptin receptor | ||
| Ligand | BDBM50100986 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1452449 (CHEMBL3362473) | ||
| Ki | 4.4±n/a nM | ||
| Citation |  Schunk, S; Linz, K; Frormann, S; Hinze, C; Oberbörsch, S; Sundermann, B; Zemolka, S; Englberger, W; Germann, T; Christoph, T; Kögel, BY; Schröder, W; Harlfinger, S; Saunders, D; Kless, A; Schick, H; Sonnenschein, H Discovery of Spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amines as Potent NOP and Opioid Receptor Agonists. ACS Med Chem Lett5:851-6 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Nociceptin receptor | |||
| Name: | Nociceptin receptor | ||
| Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 40702.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41146 | ||
| Residue: | 370 | ||
| Sequence: |
| ||
| BDBM50100986 | |||
| n/a | |||
| Name | BDBM50100986 | ||
| Synonyms: | CHEMBL3325747 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H30ClNO | ||
| Mol. Mass. | 359.933 | ||
| SMILES | Cl.CN(C)[C@@]1(CC[C@@](O)(CCc2ccccc2)CC1)c1ccccc1 |r,wU:4.2,wD:7.7,(40.86,-10.61,;38.57,-8.8,;37.23,-8.03,;37.23,-6.49,;35.9,-8.81,;35.12,-7.48,;33.58,-7.48,;32.82,-8.82,;31.48,-8.05,;31.49,-9.59,;31.5,-11.12,;30.17,-11.91,;28.83,-11.15,;27.51,-11.93,;27.52,-13.47,;28.87,-14.23,;30.19,-13.45,;33.59,-10.14,;35.13,-10.14,;36.69,-10.13,;35.95,-11.47,;36.75,-12.79,;38.29,-12.76,;39.03,-11.4,;38.23,-10.09,)| | ||
| Structure | 
| ||