Reaction Details | |||
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Target | Mu-type opioid receptor | ||
Ligand | BDBM50101112 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1453325 (CHEMBL3366609) | ||
Ki | 46±n/a nM | ||
Citation | Schunk, S; Linz, K; Hinze, C; Frormann, S; Oberbörsch, S; Sundermann, B; Zemolka, S; Englberger, W; Germann, T; Christoph, T; Kögel, BY; Schröder, W; Harlfinger, S; Saunders, D; Kless, A; Schick, H; Sonnenschein, H Discovery of a Potent Analgesic NOP and Opioid Receptor Agonist: Cebranopadol. ACS Med Chem Lett5:857-62 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Mu-type opioid receptor | |||
Name: | Mu-type opioid receptor | ||
Synonyms: | M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1 | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 44789.51 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P35372 | ||
Residue: | 400 | ||
Sequence: |
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BDBM50101112 | |||
n/a | |||
Name | BDBM50101112 | ||
Synonyms: | CHEMBL3325958 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H35FN2O8 | ||
Mol. Mass. | 570.6059 | ||
SMILES | OC(=O)CC(O)(CC(O)=O)C(O)=O.CN(C)[C@@]1(CC[C@@]2(CC1)OCCc1c2[nH]c2ccc(F)cc12)c1ccccc1 |r,wU:19.21,16.14,(17.32,-17.54,;18.64,-18.31,;19.96,-17.54,;18.64,-19.83,;17.32,-20.6,;15.99,-19.83,;18.07,-21.92,;19.6,-21.92,;20.36,-23.25,;20.37,-20.6,;16.55,-21.91,;17.31,-23.24,;15.02,-21.91,;10.36,-24.59,;8.87,-25,;7.78,-23.92,;8.48,-26.5,;7.72,-25.17,;6.18,-25.16,;5.41,-26.49,;6.18,-27.82,;7.7,-27.83,;4.5,-27.75,;2.96,-27.59,;2.33,-26.17,;3.24,-24.92,;4.78,-25.09,;5.41,-23.67,;4.26,-22.63,;4.26,-21.08,;2.92,-20.31,;1.59,-21.09,;.25,-20.31,;1.59,-22.64,;2.92,-23.41,;10.02,-26.51,;10.78,-27.85,;12.32,-27.86,;13.1,-26.53,;12.33,-25.18,;10.79,-25.18,)| | ||
Structure |