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TargetDNA-3-methyladenine glycosylase
LigandBDBM26658
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1463504 (CHEMBL3398686)
IC50 2600±n/a nM
Citation Dixon, MWoodrick, JGupta, SKarmahapatra, SKDevito, SVasudevan, SDakshanamurthy, SAdhikari, SYenugonda, VMRoy, R Naturally occurring polyphenol, morin hydrate, inhibits enzymatic activity of N-methylpurine DNA glycosylase, a DNA repair enzyme with various roles in human disease. Bioorg Med Chem23:1102-11 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA-3-methyladenine glycosylase
Name:DNA-3-methyladenine glycosylase
Synonyms:3-alkyladenine DNA glycosylase | 3-methyladenine DNA glycosidase | 3MG_HUMAN | AAG | ADPG | ANPG | MID1 | MPG | N-methylpurine-DNA glycosylase
Type:PROTEIN
Mol. Mass.:32883.92
Organism:Homo sapiens (Human)
Description:ChEMBL_109564
Residue:298
Sequence:
MVTPALQMKKPKQFCRRMGQKKQRPARAGQPHSSSDAAQAPAEQPHSSSDAAQAPCPRER
CLGPPTTPGPYRSIYFSSPKGHLTRLGLEFFDQPAVPLARAFLGQVLVRRLPNGTELRGR
IVETEAYLGPEDEAAHSRGGRQTPRNRGMFMKPGTLYVYIIYGMYFCMNISSQGDGACVL
LRALEPLEGLETMRQLRSTLRKGTASRVLKDRELCSGPSKLCQALAINKSFDQRDLAQDE
AVWLERGPLEPSEPAVVAAARVGVGHAGEWARKPLRFYVRGSPWVSVVDRVAEQDTQA
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  Blast E-value cutoff:
BDBM26658
n/a
NameBDBM26658
Synonyms:2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopyran-4-one | 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one | 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone | 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one | 2-[2,4-bis(oxidanyl)phenyl]-3,5,7-tris(oxidanyl)chromen-4-one | CHEMBL28626 | MLS000069618 | Morin (19) | Morin (5) | Morin (Mor) | SMR000058259 | cid_5281670 | morin
TypeFlavonoid
Emp. Form.C15H10O7
Mol. Mass.302.2357
SMILESOc1ccc(c(O)c1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Structure
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