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TargetDNA-3-methyladenine glycosylase
LigandBDBM67690
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1463504 (CHEMBL3398686)
IC50 2500±n/a nM
Citation Dixon, M; Woodrick, J; Gupta, S; Karmahapatra, SK; Devito, S; Vasudevan, S; Dakshanamurthy, S; Adhikari, S; Yenugonda, VM; Roy, R Naturally occurring polyphenol, morin hydrate, inhibits enzymatic activity of N-methylpurine DNA glycosylase, a DNA repair enzyme with various roles in human disease. Bioorg Med Chem23:1102-11 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA-3-methyladenine glycosylase
Name:DNA-3-methyladenine glycosylase
Synonyms:3-alkyladenine DNA glycosylase | 3-methyladenine DNA glycosidase | 3MG_HUMAN | AAG | ADPG | ANPG | MID1 | MPG | N-methylpurine-DNA glycosylase
Type:PROTEIN
Mol. Mass.:32883.92
Organism:Homo sapiens (Human)
Description:ChEMBL_109564
Residue:298
Sequence:
MVTPALQMKKPKQFCRRMGQKKQRPARAGQPHSSSDAAQAPAEQPHSSSDAAQAPCPRER
CLGPPTTPGPYRSIYFSSPKGHLTRLGLEFFDQPAVPLARAFLGQVLVRRLPNGTELRGR
IVETEAYLGPEDEAAHSRGGRQTPRNRGMFMKPGTLYVYIIYGMYFCMNISSQGDGACVL
LRALEPLEGLETMRQLRSTLRKGTASRVLKDRELCSGPSKLCQALAINKSFDQRDLAQDE
AVWLERGPLEPSEPAVVAAARVGVGHAGEWARKPLRFYVRGSPWVSVVDRVAEQDTQA
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  Blast E-value cutoff:
BDBM67690
n/a
NameBDBM67690
Synonyms:1,4-bis[2-(2-hydroxyethylamino)ethylamino]-5,8-bis(oxidanyl)anthracene-9,10-dione;hydrochloride | 1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]-9,10-anthraquinone;hydrochloride | 1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione;hydrochloride | DHAD | MITOXANTRONE | MITOXANTRONE DIHYDROCHLORIDE | MLS001333711 | SMR000058480 | cid_4212 | cid_5458171
TypeSmall organic molecule
Emp. Form.C22H28N4O6
Mol. Mass.444.4809
SMILESOCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12
Structure
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