Reaction Details |
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Target | Stromelysin-2 |
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Ligand | BDBM11863 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1431425 (CHEMBL3389268) |
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IC50 | 0.540000±n/a nM |
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Citation | Nara, H; Sato, K; Naito, T; Mototani, H; Oki, H; Yamamoto, Y; Kuno, H; Santou, T; Kanzaki, N; Terauchi, J; Uchikawa, O; Kori, M Discovery of novel, highly potent, and selective quinazoline-2-carboxamide-based matrix metalloproteinase (MMP)-13 inhibitors without a zinc binding group using a structure-based design approach. J Med Chem57:8886-902 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Stromelysin-2 |
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Name: | Stromelysin-2 |
Synonyms: | MMP10 | MMP10_HUMAN | Matrix Metalloproteinase-10 (MMP-10) | Matrix metalloproteinase 10 | STMY2 |
Type: | Enzyme |
Mol. Mass.: | 54143.02 |
Organism: | Homo sapiens (Human) |
Description: | P09238 |
Residue: | 476 |
Sequence: | MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV
KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY
TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL
AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN
SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST
LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW
AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG
FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
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BDBM11863 |
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n/a |
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Name | BDBM11863 |
Synonyms: | 4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N-hydroxyoxane-4-carboxamide | CHEMBL440498 | RS 130830 | RS-130,830 | alpha-tetrahydropyran beta-sulfone 1B |
Type | Small organic molecule |
Emp. Form. | C19H20ClNO6S |
Mol. Mass. | 425.883 |
SMILES | ONC(=O)C1(CS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)CCOCC1 |
Structure |
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