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TargetVoltage-gated potassium channel beta subunit Mink
LigandBDBM50103543
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1434849
IC50 27000±n/a nM
Citation Scott JSBowker SSBrocklehurst KJBrown HSClarke DSEaster AErtan AGoldberg KHudson JAKavanagh SLaber DLeach AGMacFaul PAMartin EAMcKerrecher DSchofield PSvensson PHTeague J Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonists. J Med Chem 57:8984-98 (2014) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Voltage-gated potassium channel beta subunit Mink
Name:Voltage-gated potassium channel beta subunit Mink
Synonyms:Delayed rectifier potassium channel subunit IsK | IKs producing slow voltage-gated potassium channel subunit beta Mink | KCNQ1(Kv7.1)/KCNE1(MinK) | Minimal potassium channel | Voltage-gated potassium channel, IKs
Type:PROTEIN
Mol. Mass.:14676.11
Organism:Homo sapiens (Human)
Description:ChEMBL_1456351
Residue:129
Sequence:
MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLG
IMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNT
HLPETKPSP
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BDBM50103543
n/a
NameBDBM50103543
Synonyms:CHEMBL3358006
TypeSmall organic molecule
Emp. Form.C21H22F4N6O4S
Mol. Mass.530.496
SMILESC[C@@H]1CN(CCN1c1ncc(OCc2ccc(CS(C)(=O)=O)cc2F)cn1)c1nc(no1)C(F)(F)F |r|
Structure
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