| Reaction Details |
|---|
 | Report a problem with these data |
| Target | L-lactate dehydrogenase A chain |
|---|
| Ligand | BDBM50052254 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1435605 (CHEMBL3386528) |
|---|
| IC50 | 870±n/a nM |
|---|
| Citation |  Granchi, C; Fancelli, D; Minutolo, F An update on therapeutic opportunities offered by cancer glycolytic metabolism. Bioorg Med Chem Lett24:4915-25 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| L-lactate dehydrogenase A chain |
|---|
| Name: | L-lactate dehydrogenase A chain |
|---|
| Synonyms: | Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 36694.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00338::PDB Code: 4ajp |
|---|
| Residue: | 332 |
|---|
| Sequence: | MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
|
|
|
|---|
| BDBM50052254 |
|---|
| n/a |
|---|
| Name | BDBM50052254 |
|---|
| Synonyms: | 2',6'-dichloro-4-((2-chlorophenyl)thio)-5-hydroxy-1,6-dihydro-[1,1'-biphenyl]-3(2H)-one (3) | CHEMBL3318469 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H13Cl3O2S |
|---|
| Mol. Mass. | 399.719 |
|---|
| SMILES | OC1=C(Sc2ccccc2Cl)C(=O)CC(C1)c1c(Cl)cccc1Cl |c:1| |
|---|
| Structure | 
|
|---|
Search and Browse
