| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 4 |
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| Ligand | BDBM29589 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1484271 (CHEMBL3538487) |
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| IC50 | 200±n/a nM |
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| Citation |  Fredenhagen, A; Kittelmann, M; Oberer, L; Kuhn, A; Kühnöl, J; Délémonté, T; Aichholz, R; Wang, P; Atadja, P; Shultz, MD Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589). Drug Metab Dispos40:1041-50 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 4 |
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| Name: | Histone deacetylase 4 |
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| Synonyms: | Cereblon/Histone deacetylase 4 | HD4 | HDAC4 | HDAC4_HUMAN | Histone acetylase 4(HDAC4) | Human HDAC4 | KIAA0288 |
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| Type: | Enzyme |
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| Mol. Mass.: | 119049.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P56524 |
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| Residue: | 1084 |
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| Sequence: | MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP
VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA
MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL
NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP
LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP
SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA
TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL
EQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHL
VIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPY
LDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ
RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDT
LMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT
LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE
LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWD
VHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP
PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL
MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV
MEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEE
EPPL
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| BDBM29589 |
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| n/a |
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| Name | BDBM29589 |
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| Synonyms: | Faridak | LBH-589 | LBH-589B | Panobinostat | US10722597, Compound Panobinostat |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23N3O2 |
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| Mol. Mass. | 349.4262 |
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| SMILES | Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1 |
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| Structure | 
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