| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP3 [R100H] |
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| Ligand | BDBM50104286 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1505400 (CHEMBL3595283) |
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| IC50 | 13000±n/a nM |
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| Citation |  Nkizinkiko, Y; Suneel Kumar, BV; Jeankumar, VU; Haikarainen, T; Koivunen, J; Madhuri, C; Yogeeswari, P; Venkannagari, H; Obaji, E; Pihlajaniemi, T; Sriram, D; Lehtiö, L Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics. Bioorg Med Chem23:4139-49 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP3 [R100H] |
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| Name: | Protein mono-ADP-ribosyltransferase PARP3 [R100H] |
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| Synonyms: | (ARTD3 or PARP3) | ADP-ribosyltransferase diphtheria toxin-like 3 | ADPRT3 | ADPRTL3 | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD3 or PARP3) | PARP3 | PARP3_HUMAN | Poly [ADP-ribose] polymerase 3 | Poly [ADP-ribose] polymerase 3 (PARP-3) | Poly(ADP-ribose) polymerase-3 (ARTD3/PARP3) |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60071.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y6F1[R100H] |
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| Residue: | 533 |
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| Sequence: | MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGT
QVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNHWGRVGEVGQSKINHFTRLED
AKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRV
QPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEAL
KGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQA
VSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWK
VNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENS
KSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPT
QDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
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| BDBM50104286 |
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| n/a |
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| Name | BDBM50104286 |
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| Synonyms: | CHEMBL3593715 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H23N5O |
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| Mol. Mass. | 325.4081 |
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| SMILES | O=c1[nH]c(nc2CCCCc12)N1CCN(Cc2ccncc2)CC1 |
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| Structure | 
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