| Reaction Details |
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 | Report a problem with these data |
| Target | Translocator protein |
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| Ligand | BDBM50104772 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1508094 (CHEMBL3599695) |
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| Ki | 0.370000±n/a nM |
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| Citation |  Barresi, E; Bruno, A; Taliani, S; Cosconati, S; Da Pozzo, E; Salerno, S; Simorini, F; Daniele, S; Giacomelli, C; Marini, AM; La Motta, C; Marinelli, L; Cosimelli, B; Novellino, E; Greco, G; Da Settimo, F; Martini, C Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides. J Med Chem58:6081-92 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Translocator protein |
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| Name: | Translocator protein |
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| Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
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| Type: | Mitochondrion membrane protein |
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| Mol. Mass.: | 18945.84 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
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| Residue: | 169 |
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| Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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| BDBM50104772 |
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| n/a |
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| Name | BDBM50104772 |
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| Synonyms: | CHEMBL3597381 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26N2O2 |
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| Mol. Mass. | 398.4968 |
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| SMILES | CCCCCN(C)C(=O)C(=O)c1c([nH]c2ccccc12)-c1ccc2ccccc2c1 |
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| Structure | 
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