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TargetTranslocator protein
LigandBDBM50104792
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1508094 (CHEMBL3599695)
Ki 4.2±n/a nM
Citation Barresi, EBruno, ATaliani, SCosconati, SDa Pozzo, ESalerno, SSimorini, FDaniele, SGiacomelli, CMarini, AMLa Motta, CMarinelli, LCosimelli, BNovellino, EGreco, GDa Settimo, FMartini, C Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides. J Med Chem58:6081-92 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Translocator protein
Name:Translocator protein
Synonyms:Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:Mitochondrion membrane protein
Mol. Mass.:18945.84
Organism:Rattus norvegicus (rat)
Description:Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50104792
n/a
NameBDBM50104792
Synonyms:CHEMBL3597361
TypeSmall organic molecule
Emp. Form.C28H37N3O2
Mol. Mass.447.6123
SMILESCCCCCCN(CCCCCC)C(=O)C(=O)c1c([nH]c2ccccc12)-c1ccc(N)cc1
Structure
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