Reaction Details |
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Target | Cysteinyl leukotriene receptor 1 |
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Ligand | BDBM50104837 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1506282 (CHEMBL3599260) |
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IC50 | 3.4±n/a nM |
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Citation | Itadani, S; Yashiro, K; Aratani, Y; Sekiguchi, T; Kinoshita, A; Moriguchi, H; Ohta, N; Takahashi, S; Ishida, A; Tajima, Y; Hisaichi, K; Ima, M; Ueda, J; Egashira, H; Sekioka, T; Kadode, M; Yonetomi, Y; Nakao, T; Inoue, A; Nomura, H; Kitamine, T; Fujita, M; Nabe, T; Yamaura, Y; Matsumura, N; Imagawa, A; Nakayama, Y; Takeuchi, J; Ohmoto, K Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma. J Med Chem58:6093-113 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cysteinyl leukotriene receptor 1 |
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Name: | Cysteinyl leukotriene receptor 1 |
Synonyms: | CLTR1_HUMAN | CYSLT1 | CYSLTR1 | Cysteinyl leukotriene D4 receptor | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 1 | HG55 | HMTMF81 | LTD4 receptor | Leukotriene Cysteinyl 1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 38565.16 |
Organism: | Homo sapiens (Human) |
Description: | Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271 |
Residue: | 337 |
Sequence: | MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQV
YMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFF
RCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDN
QTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTA
AFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGG
NFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
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BDBM50104837 |
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n/a |
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Name | BDBM50104837 |
Synonyms: | CHEMBL3597523 |
Type | Small organic molecule |
Emp. Form. | C32H33NO5 |
Mol. Mass. | 511.6081 |
SMILES | OC(=O)CCCc1cn(CC(O)=O)c2c(\C=C\c3ccc(OCCCCc4ccccc4)cc3)cccc12 |
Structure |
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