Reaction Details |
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Target | Cysteinyl leukotriene receptor 2 |
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Ligand | BDBM50104921 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1506283 (CHEMBL3599261) |
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IC50 | 25±n/a nM |
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Citation | Itadani, S; Yashiro, K; Aratani, Y; Sekiguchi, T; Kinoshita, A; Moriguchi, H; Ohta, N; Takahashi, S; Ishida, A; Tajima, Y; Hisaichi, K; Ima, M; Ueda, J; Egashira, H; Sekioka, T; Kadode, M; Yonetomi, Y; Nakao, T; Inoue, A; Nomura, H; Kitamine, T; Fujita, M; Nabe, T; Yamaura, Y; Matsumura, N; Imagawa, A; Nakayama, Y; Takeuchi, J; Ohmoto, K Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma. J Med Chem58:6093-113 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cysteinyl leukotriene receptor 2 |
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Name: | Cysteinyl leukotriene receptor 2 |
Synonyms: | CLTR2_HUMAN | CYSLT2 | CYSLT2R | CYSLTR2 | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 2 | Leukotriene Cysteinyl 2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 39657.52 |
Organism: | Homo sapiens (Human) |
Description: | Leukotriene Cysteinyl 2 CYSLTR2 HUMAN::Q9NS75 |
Residue: | 346 |
Sequence: | MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSI
YVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYV
NMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQ
NGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRV
SHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACF
NPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
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BDBM50104921 |
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n/a |
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Name | BDBM50104921 |
Synonyms: | CHEMBL3597634 |
Type | Small organic molecule |
Emp. Form. | C36H37F2NO5 |
Mol. Mass. | 601.6795 |
SMILES | Cc1c(CCCC(O)=O)c2c(F)ccc(C#Cc3ccc(OCCCCc4cccc(F)c4C)cc3)c2n1CCCC(O)=O |
Structure |
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