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TargetCysteinyl leukotriene receptor 1
LigandBDBM50104918
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1506309 (CHEMBL3599287)
IC50 2.6±n/a nM
Citation Itadani, SYashiro, KAratani, YSekiguchi, TKinoshita, AMoriguchi, HOhta, NTakahashi, SIshida, ATajima, YHisaichi, KIma, MUeda, JEgashira, HSekioka, TKadode, MYonetomi, YNakao, TInoue, ANomura, HKitamine, TFujita, MNabe, TYamaura, YMatsumura, NImagawa, ANakayama, YTakeuchi, JOhmoto, K Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma. J Med Chem58:6093-113 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cysteinyl leukotriene receptor 1
Name:Cysteinyl leukotriene receptor 1
Synonyms:CLTR1_CAVPO | CYSLTR1
Type:Enzyme Catalytic Domain
Mol. Mass.:39007.58
Organism:GUINEA PIG
Description:Leukotriene D4 0 GUINEA PIG::Q2NNR5
Residue:340
Sequence:
MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSA
FQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAM
SFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPP
QDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIV
VTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFF
SGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
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  Blast E-value cutoff:
BDBM50104918
n/a
NameBDBM50104918
Synonyms:CHEMBL3597631
TypeSmall organic molecule
Emp. Form.C35H33F4NO5
Mol. Mass.623.6338
SMILESCc1c(CCCC(O)=O)c2cccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(O)=O
Structure
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