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TargetEndothelial PAS domain-containing protein 1
LigandBDBM50105278
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1506506 (CHEMBL3599972)
IC50 108±n/a nM
Citation Scheuermann, THStroud, DSleet, CEBayeh, LShokri, CWang, HCaldwell, CGLonggood, JMacMillan, JBBruick, RKGardner, KHTambar, UK Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2. J Med Chem58:5930-41 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Endothelial PAS domain-containing protein 1
Name:Endothelial PAS domain-containing protein 1
Synonyms:BHLHE73 | EPAS1 | EPAS1_HUMAN | HIF2A | MOP2 | PASD2 | endothelial PAS domain-containing protein 1
Type:PROTEIN
Mol. Mass.:96453.58
Organism:Homo sapiens (Human)
Description:ChEMBL_1506501
Residue:870
Sequence:
MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA
ISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMG
LTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRG
RTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLD
SKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTE
SLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQN
FEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCS
TPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDF
QLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPE
HRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTE
FLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQ
DLSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHL
PLPQPPSAISPGENSKSRFPPQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELT
RYDCEVNVPVLGSSTLLQGGDLLRALDQAT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50105278
n/a
NameBDBM50105278
Synonyms:CHEMBL3597778
TypeSmall organic molecule
Emp. Form.C16H13BrIN5
Mol. Mass.482.116
SMILESBrc1cccc(c1)[C@@H]1C[C@H](c2cccc(I)c2)n2nnnc2N1 |r|
Structure
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