| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 3 |
|---|
| Ligand | BDBM50105327 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1506755 (CHEMBL3598914) |
|---|
| Ki | 2.1±n/a nM |
|---|
| Citation |  Carrillo, AK; Guiguemde, WA; Guy, RK Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT). Bioorg Med Chem23:5151-5 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 3 |
|---|
| Name: | Histone deacetylase 3 |
|---|
| Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48829.55 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O15379 |
|---|
| Residue: | 428 |
|---|
| Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
|
|
|
|---|
| BDBM50105327 |
|---|
| n/a |
|---|
| Name | BDBM50105327 |
|---|
| Synonyms: | JNJ-26481585 | Quisinostat |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H26N6O2 |
|---|
| Mol. Mass. | 394.4701 |
|---|
| SMILES | Cn1cc(CNCC2CCN(CC2)c2ncc(cn2)C(=O)NO)c2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
