| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Ligand | BDBM50105870 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1507783 (CHEMBL3598540) |
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| IC50 | 17±n/a nM |
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| Citation |  Pelcman, B; Sanin, A; Nilsson, P; Schaal, W; Olofsson, K; Krog-Jensen, C; Forsell, P; Hallberg, A; Larhed, M; Boesen, T; Kromann, H; Claesson, HE N-Substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase. Bioorg Med Chem Lett25:3017-23 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Synonyms: | 15-Lipoxygenase-1 (15-LOX-1) | ALOX15 | Arachidonate 15-lipoxygenase | Arachidonate 15-lipoxygenase-1 | LOG15 | LOX15_HUMAN | Reticulocyte 15-lipoxygenase-1 | Sphingosine 1-phosphate receptor 1 (S1P1) |
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| Type: | Protein |
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| Mol. Mass.: | 74804.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 662 |
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| Sequence: | MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL
LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP
QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK
GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV
LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL
VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH
LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST
GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS
LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH
ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ
PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV
AI
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| BDBM50105870 |
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| n/a |
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| Name | BDBM50105870 |
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| Synonyms: | CHEMBL3597768 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H12ClFN4O3S |
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| Mol. Mass. | 418.829 |
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| SMILES | Fc1ccc(NC(=O)c2ccn(n2)C(=S)Nc2ccc3OCOc3c2)c(Cl)c1 |
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| Structure | 
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