| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
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| Ligand | BDBM50105912 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1508026 (CHEMBL3599516) |
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| IC50 | 2200±n/a nM |
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| Citation |  Yadav, RR; Sharma, S; Joshi, P; Wani, A; Vishwakarma, RA; Kumar, A; Bharate, SB Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. Bioorg Med Chem Lett25:2948-52 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
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| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
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| Synonyms: | DYRK3 | DYRK3_HUMAN | Dual-specificity tyrosine-phosphorylation regulated kinase 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65747.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1508026 |
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| Residue: | 588 |
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| Sequence: | MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR
RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS
SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG
VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV
RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK
KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC
FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC
MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS
KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR
VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS
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| BDBM50105912 |
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| n/a |
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| Name | BDBM50105912 |
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| Synonyms: | CHEMBL3133762 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16BrN5O2 |
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| Mol. Mass. | 402.245 |
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| SMILES | Nc1nccc(n1)-c1cn(C(=O)N2CCOCC2)c2ccc(Br)cc12 |
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| Structure | 
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