Reaction Details |
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Target | Substance-P receptor |
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Ligand | BDBM50106380 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1506611 (CHEMBL3598468) |
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IC50 | 5.0±n/a nM |
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Citation | Degnan, AP; Tora, GO; Han, Y; Rajamani, R; Bertekap, R; Krause, R; Davis, CD; Hu, J; Morgan, D; Taylor, SJ; Krause, K; Li, YW; Mattson, G; Cunningham, MA; Taber, MT; Lodge, NJ; Bronson, JJ; Gillman, KW; Macor, JE Biaryls as potent, tunable dual neurokinin 1 receptor antagonists and serotonin transporter inhibitors. Bioorg Med Chem Lett25:3039-43 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Substance-P receptor |
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Name: | Substance-P receptor |
Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R_RAT | Neurokinin 1 receptor | Neurokinin NK1 | SPR | Substance-P receptor | Tac1r | Tachykinin receptor 1 | Tacr1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46371.54 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected CHO cells that constitutively expressed the rat NK1 receptor. |
Residue: | 407 |
Sequence: | MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAH
KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTIST
VVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
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BDBM50106380 |
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n/a |
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Name | BDBM50106380 |
Synonyms: | CHEMBL3596468 |
Type | Small organic molecule |
Emp. Form. | C26H25F4NO |
Mol. Mass. | 443.4764 |
SMILES | Fc1cccc(c1)-c1cc(COCC2(CCNCC2)c2ccccc2)cc(c1)C(F)(F)F |
Structure |
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